Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice.

doi:10.1002/em.22058

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Article

Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice.

Environmental and molecular mutagenesis - 1 Dec 2016

Wickliffe Jeffrey K, Dertinger Stephen D, Torous Dorothea K, Avlasevich Svetlana L, Simon-Friedt Bridget R, Wilson Mark J

Abstract excerpt

Obesity increases the risk of a number of chronic diseases in humans including several cancers. Biological mechanisms responsible for such increased risks are not well understood at present. Increases in systemic inflammation and oxidative stress, endogenous production of mutagenic metabolites, altered signaling in proliferative pathways, and increased sensitivity to exogenous mutagens and carcinogens are some of...

Topics

Aging
Animals
Biomarkers
Diet, High-Fat
Erythrocytes
Ethylnitrosourea
Male
Membrane Proteins
Mice, Inbred C57BL
Micronuclei, Chromosome-Defective
Mutagenicity Tests
Mutation
Obesity

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Identifiers

PMID: 27739633
DOI: 10.1002/em.22058
PMCID: PMC5118159

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