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Article

Mutatomics analysis of the systematic thermostability profile of Bacillus subtilis lipase A.

Journal of molecular modeling - 1 Jun 2014

Tian Feifei, Yang Cao, Wang Congcong, Guo Tailin, Zhou Peng

Abstract excerpt

Use of point mutagenesis technique to improve protein thermostability is a routine strategy in the protein engineering community and directed evolution approach has been widely utilized to fulfill this. However, directed evolution often does not assure a minimalist design for obtaining a desired property in proteins, and other traditional methods such as error-prone PCR and iterative saturation mutagenesis are...

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PMID: 24827611
DOI: 10.1007/s00894-014-2257-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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