Engineering lipase A from mesophilic Bacillus subtilis for activity at low temperatures.

doi:10.1093/protein/gzt064

Back to search

Article

Engineering lipase A from mesophilic Bacillus subtilis for activity at low temperatures.

Protein engineering, design & selection : PEDS - 1 Mar 2014

Kumar Virender, Yedavalli Poornima, Gupta Vishal, Rao Nalam Madhusudhana

Abstract excerpt

Loops or unordered regions of a protein are structurally dynamic and are strongly implicated in activity, stability and proteolytic susceptibility of proteins. Diminished activity of proteins at lower temperatures is considered to be due to compromised dynamics of the protein at lower temperature...

Topics

Bacillus subtilis
Bacterial Proteins
Cold Temperature
Enzyme Stability
Lipase
Molecular Dynamics Simulation
Mutagenesis, Site-Directed
Mutation
Protein Conformation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.