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Article

Engineering lipase A from mesophilic Bacillus subtilis for activity at low temperatures.

Protein engineering, design & selection : PEDS - 1 Mar 2014

Kumar Virender, Yedavalli Poornima, Gupta Vishal, Rao Nalam Madhusudhana

Abstract excerpt

Loops or unordered regions of a protein are structurally dynamic and are strongly implicated in activity, stability and proteolytic susceptibility of proteins. Diminished activity of proteins at lower temperatures is considered to be due to compromised dynamics of the protein at lower temperatures. To evolve an active mesophilic lipase (Bacillus subtilis) at low temperatures, we subjected all the loop residues (n...

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PMID: 24402332
DOI: 10.1093/protein/gzt064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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