Thermostable Bacillus subtilis lipases: in vitro evolution and structural insight.

doi:10.1016/j.jmb.2008.05.063

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Article

Thermostable Bacillus subtilis lipases: in vitro evolution and structural insight.

Journal of molecular biology - 29 Aug 2008

Ahmad Shoeb, Kamal Md Zahid, Sankaranarayanan Rajan, Rao N Madhusudhana

Abstract excerpt

In vitro evolution methods are now being routinely used to identify protein variants with novel and enhanced properties that are difficult to achieve using rational design. However, one of the limitations is in screening for beneficial mutants through several generations due to the occurrence of...

Topics

Bacillus subtilis
Bacterial Proteins
Crystallography, X-Ray
Directed Molecular Evolution
Hydrogen Bonding
Lipase
Mutagenesis
Mutation
Polymerase Chain Reaction
Protein Structure, Secondary
Protein Structure, Tertiary
Temperature
Thermodynamics
Water

Source

Open in PubMed

Identifiers

PMID: 18599073
DOI: 10.1016/j.jmb.2008.05.063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18599073-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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