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Article

The role of TPA I/D and PAI-1 4G/5G polymorphisms in multiple sclerosis.

Disease markers - 1 Jan 2014

Zivković Maja, Starčević Čizmarević Nada, Lovrečić Luca, Klupka-Sarić Inge, Stanković Aleksandra, Gašparović Iva, Lavtar Polona, Dinčić Evica, Stojković Ljiljana, Rudolf Gorazd, Jazbec Saša Sega, Perković Olivio, Sinanović Osman, Sepčić Juraj, Kapović Miljenko, Peterlin Borut, Ristić Smiljana

Abstract excerpt

BACKGROUND: Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G...

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Identifiers

PMID: 24825926
DOI: 10.1155/2014/362708
PMCID: PMC4009184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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