Article
Association between the -844 G>A, HindIII C>G, and 4G/5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population.
Disease markers - 1 Jan 2019
Valdés-Alvarado Emmanuel, Huerta Miguel, Trujillo Xochil, Valle Yeminia, Padilla Gutiérrez Jorge Ramón, Mireles-Ramírez Mario Alberto, Macías-Islas Miguel Angel, Luz Margarita Baltazar-Rodríguez, Muñoz-Valle José Francisco
Abstract excerpt
INTRODUCTION: Multiple sclerosis is an inflammatory disease, where fibrin deposition and the impairment in its degradation have been shown to play an important role in the demyelination process. Tissue plasminogen activator (tPA) is a serine protease that enhances the conversion of plasminogen into its active form plasmin, the principal tPA inhibitor is the PAI-1. Several PAI-1 polymorphisms impact its gene...
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