Article
Angiotensin-converting enzyme gene polymorphism in patients with multiple sclerosis from Bosnia and Herzegovina.
Genetic testing and molecular biomarkers - 1 Nov 2011
Klupka-Sarić Inge, Peterlin Borut, Lovrečić Luca, Sinanović Osman, Vidović Mirjana, Sehanović Aida, Cizmarević Nada Starčević, Sepčić Juraj, Kapović Miljenko, Ristić Smiljana
Abstract excerpt
BACKGROUND: Increased activity of angiotensin-converting enzyme (ACE) in the blood and cerebrospinal fluid of patients with multiple sclerosis (MS), and the inhibition of ACE in experimental autoimmune encephalomyelitis, suggested that ACE may play a role in the pathogenesis and progression of MS. We recently published the first report on the potential association of MS and ACE I/D polymorphism in Slovenian and...
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