Article
Plasminogen activator inhibitor 1 gene and risk of MS in women.
Neurology - 9 May 2000
Luomala M, Elovaara I, Ukkonen M, Koivula T, Lehtimäki T
Abstract excerpt
In view of the potential importance of the proteolytic mechanisms in the evolution of MS lesions, the authors studied the 4G/5G promoter polymorphism of the plasminogen activator inhibitor 1 (PAI-1) gene in the susceptibility of MS. The 5G5G genotype was associated with MS in women at an odds ratio of 2.3 (95% confidence interval, 1.04 to 5.23). The genotype seems to be a low producer of PAI-1, suggesting that...
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