Article
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients.
G3 (Bethesda, Md.) - 7 Jul 2016
Sadovnick A Dessa, Traboulsee Anthony L, Bernales Cecily Q, Ross Jay P, Forwell Amanda L, Yee Irene M, Guillot-Noel Lena, Fontaine Bertrand, Cournu-Rebeix Isabelle, Alcina Antonio, Fedetz Maria, Izquierdo Guillermo, Matesanz Fuencisla, Hilven Kelly, Dubois Bénédicte, Goris An, Astobiza Ianire, Alloza Iraide, Antigüedad Alfredo, Vandenbroeck Koen, Akkad Denis A, Aktas Orhan, Blaschke Paul, Buttmann Mathias, Chan Andrew, Epplen Joerg T, Gerdes Lisa-Ann, Kroner Antje, Kubisch Christian, Kümpfel Tania, Lohse Peter, Rieckmann Peter, Zettl Uwe K, Zipp Frauke, Bertram Lars, Lill Christina M, Fernandez Oscar, Urbaneja Patricia, Leyva Laura, Alvarez-Cermeño Jose Carlos, Arroyo Rafael, Garagorri Aroa M, García-Martínez Angel, Villar Luisa M, Urcelay Elena, Malhotra Sunny, Montalban Xavier, Comabella Manuel, Berger Thomas, Fazekas Franz, Reindl Markus, Schmied Mascha C, Zimprich Alexander, Vilariño-Güell Carles
Abstract excerpt
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. Genotyping of PLG p.G420D (rs139071351) in 2160 MS patients, and 886 controls from Canada, identified 10 additional probands, two sporadic patients and...
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