Article
Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia.
Journal of the neurological sciences - 15 Apr 2008
Djurić Tamara, Zivković Maja, Stanković Aleksandra, Dincić Evica, Raicević Ranko, Alavantić Dragan
Abstract excerpt
Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from...
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