Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case-control study.

doi:10.1007/s10072-021-05608-1

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Article

Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case-control study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2022

Abbadessa Gianmarco, Miele Giuseppina, Di Pietro Andrea, Sparaco Maddalena, Palladino Raffaele, Armetta Ignazio, D'Elia Giovanna, Trojsi Francesca, Signoriello Elisabetta, Lus Giacomo, Lavorgna Luigi, Bonavita Simona

Abstract excerpt

INTRODUCTION: Blood coagulation constituents might exert immunomodulatory functions in the CNS and may trigger neuroinflammation and demyelination. We evaluated whether particular single-nucleotide polymorphisms (SNPs), thought to be involved in fibrinogen-mediated hemostatic pathways, are overrepresented in patients with MS compared with controls. METHODS: The case-control study consisted of 119 MS patients...

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PMID: 34561786
DOI: 10.1007/s10072-021-05608-1
PMCID: PMC8918146

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