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Article

Association of PAI-1 4G/5G and -844G/A gene polymorphism and changes in PAI-1/tPA levels in stroke: a case-control study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2000

Saidi Sarra, Slamia Lamia B, Mahjoub Touhami, Ammou Sofyan B, Almawi Wassim Y

Abstract excerpt

Mutations in the plasminogen activator inhibitor-1 (PAI-1) gene, along with altered PAI-1 and tissue-type plasminogen activator (tPA) levels, have been implicated in stroke pathogenesis. We investigated the association of PAI-1 and tPA levels with stroke as a function of PAI-1 4G/5G and -844G/A genotypes, as well as the link between these PAI-1 gene variants and stroke risk, in a case-control study of 135...

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Identifiers

PMID: 17689411
DOI: 10.1016/j.jstrokecerebrovasdis.2007.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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