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Article

tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis.

The Journal of infectious diseases - 15 Jul 2013

Valle-Garay Eulalia, Montes Angel H, Corte Jose R, Meana Alvaro, Fierer Joshua, Asensi Victor

Abstract excerpt

BACKGROUND: Coagulation and fibrinolysis are important in infections and systemic inflammatory response syndrome. Polymorphisms in plasminogen activator inhibitor-1 (PAI-1, SERPINE1) and tissue plasminogen activator (tPA, PLAT), such as PAI-1 (-675 4G/5G deletion/insertion) and tPA (Alu insertion/deletion [I/D]), are associated with strokes, myocardial infarctions, bacterial infections and septic shock severity,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23570848
DOI: 10.1093/infdis/jit158

Genes

PLAT
SERPINE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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