Article
Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.
Current biology : CB - 2 Nov 2000
Rothenfluh A, Abodeely M, Young M W
Abstract excerpt
Circadian (24 hour) PERIOD (PER) protein oscillation is dependent on the double-time (dbt) gene, a casein kinase Ivarepsilon homolog [1-3]. Without dbt activity, hypophosphorylated PER proteins over-accumulate, indicating that dbt is required for PER phosphorylation and turnover [3,4]. There is evidence of a similar role for casein kinase Ivarepsilon in the mammalian circadian clock [5,6]. We have isolated a new...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- Casein Kinase 1 epsilon
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Genotype
- Insect Proteins
- Motor Activity
- Mutation