Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.

Current biology : CB - 2 Nov 2000

Rothenfluh A, Abodeely M, Young M W

Abstract excerpt

Circadian (24 hour) PERIOD (PER) protein oscillation is dependent on the double-time (dbt) gene, a casein kinase Ivarepsilon homolog [1-3]. Without dbt activity, hypophosphorylated PER proteins over-accumulate, indicating that dbt is required for PER phosphorylation and turnover [3,4]. There is evidence of a similar role for casein kinase Ivarepsilon in the mammalian circadian clock [5,6]. We have isolated a new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Blotting, Western
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Genotype

Share to Mutation

Share to Nuclear Proteins

Share to Phosphorylation

Source

Identifiers

PMID: 11084344
DOI: 10.1016/s0960-9822(00)00786-7

Genes

DBT
TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.PMID 11084344Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.Semantic proximity Read ↗

Casein kinase I epsilon does not rescue double-time function in Drosophila despite evolutionarily conserved roles in the circadian clock.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.