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Article

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

DNA repair - 1 Sept 2014

Ashley Amanda K, Shrivastav Meena, Nie Jingyi, Amerin Courtney, Troksa Kyle, Glanzer Jason G, Liu Shengqin, Opiyo Stephen O, Dimitrova Diana D, Le Phuong, Sishc Brock, Bailey Susan M, Oakley Greg G, Nickoloff Jac A

Abstract excerpt

Genotoxins and other factors cause replication stress that activate the DNA damage response (DDR), comprising checkpoint and repair systems. The DDR suppresses cancer by promoting genome stability, and it regulates tumor resistance to chemo- and radiotherapy. Three members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, ATM, ATR, and DNA-PK, are important DDR proteins. A key PIKK target is...

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Source

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Identifiers

PMID: 24819595
DOI: 10.1016/j.dnarep.2014.04.008
PMCID: PMC4135522

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.PMID 24819595Read ↗

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