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Article

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Nucleic acids research - 1 Nov 2012

Liu Shengqin, Opiyo Stephen O, Manthey Karoline, Glanzer Jason G, Ashley Amanda K, Amerin Courtney, Troksa Kyle, Shrivastav Meena, Nickoloff Jac A, Oakley Greg G

Abstract excerpt

DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote repair and induce programed cell death when damage is severe. Checkpoints are critical parts of the DNA damage response network that act to suppress cancer. DNA damage and perturbation of replication machinery causes replication stress,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22977173
DOI: 10.1093/nar/gks849
PMCID: PMC3510507

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.PMID 22977173Read ↗

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.Semantic proximity Read ↗

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.Semantic proximity Read ↗

In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.Semantic proximity Read ↗

DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response.Semantic proximity Read ↗

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.Semantic proximity Read ↗

Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responsesSemantic proximity Read ↗

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells.Semantic proximity Read ↗

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and RadiotherapySemantic proximity Read ↗

A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.Semantic proximity Read ↗

DNA Damage and Replication Stress CheckpointsSemantic proximity Read ↗

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapseSemantic proximity Read ↗

The DNA-PKcs/JNK/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastropheSemantic proximity Read ↗

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