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Article

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.

The Journal of biological chemistry - 22 Dec 2006

Olson Erin, Nievera Christian J, Klimovich Vitaly, Fanning Ellen, Wu Xiaohua

Abstract excerpt

Upon DNA damage, replication is inhibited by the S-phase checkpoint. ATR (ataxia telangiectasia mutated- and Rad3-related) is specifically involved in the inhibition of replicon initiation when cells are treated with DNA damage-inducing agents that stall replication forks, but the mechanism by which it acts to prevent replication is not yet fully understood. We observed that RPA2 is phosphorylated on chromatin in...

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Source

Identifiers

PMID: 17035231
DOI: 10.1074/jbc.M605121200

Genes

ATR
RPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.PMID 17035231Read ↗

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DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.Semantic proximity Read ↗

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NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapseSemantic proximity Read ↗

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