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Article

Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.

Molecular brain - 8 Oct 2020

Bono Keiko, Hara-Miyauchi Chikako, Sumi Shunsuke, Oka Hisayoshi, Iguchi Yasuyuki, Okano Hirotaka James

Abstract excerpt

Mutations in the Vacuolar protein sorting 35 (VPS35) gene have been linked to familial Parkinson's disease (PD), PARK17. VPS35 is a key component of the retromer complex, which plays a central role in endosomal trafficking. However, whether and how VPS35 deficiency or mutation contributes to PD pathogenesis remain unclear. Here, we analyzed human induced pluripotent stem cell (iPSC)-derived neurons from PD...

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Identifiers

PMID: 33032646
DOI: 10.1186/s13041-020-00675-5
PMCID: PMC7542911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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