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Article

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.

Current biology : CB - 21 Jul 2014

McGough Ian J, Steinberg Florian, Jia Da, Barbuti Peter A, McMillan Kirsty J, Heesom Kate J, Whone Alan L, Caldwell Maeve A, Billadeau Daniel D, Rosen Michael K, Cullen Peter J

Abstract excerpt

Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-spanning cargo proteins from endosomes into retrieval pathways destined for the Golgi apparatus and the plasma membrane [1]. Recently, a specific mutation in the retromer component VPS35, VPS35(D620N), has linked retromer dysfunction to familial autosomal dominant and sporadic Parkinson disease [2, 3]. However, the...

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Identifiers

PMID: 24980502
DOI: 10.1016/j.cub.2014.06.024
PMCID: PMC4110399

Genes

VPS35

Variants

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.PMID 24980502Read ↗

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagySemantic proximity Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29 and Fam21Semantic proximity Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.Semantic proximity Read ↗

The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stressSemantic proximity Read ↗

The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.Semantic proximity Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

Parkinson’s disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35Semantic proximity Read ↗

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationSemantic proximity Read ↗

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620NSemantic proximity Read ↗

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.Semantic proximity Read ↗

Role of the VPS35 D620N mutation in Parkinson's disease.Semantic proximity Read ↗

Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.Semantic proximity Read ↗

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