Article

The Parkinson’s Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

2023-12-03

Abstract excerpt

The identification of multiple genes linked to Parkinson’s Disease invites the question as to how they may cooperate. We have generated isogenic cell lines that inducibly express either wild-type or a mutant form of the retromer component VPS35 (D620N), which has been linked to Parkinson’s Disease. This has enabled us to test proposed effects of this mutation in a setting where the relative expression reflects the...

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Literature Corpus work: e57404fa-7703-51ef-bd6d-6843ddf49ade
DOI: 10.1101/2023.12.02.569621

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