Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

6 Jul 2016

Abstract excerpt

Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate receptor for lysosomal enzymes. The cycling of retromer on and off the endosomal membrane is regulated by a network of retromer-interacting proteins. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Lysosomal Storage Disorders Research
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27385586
DOI: 10.1074/jbc.m115.703157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationPMID 27385586Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.Semantic proximity Read ↗

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.Semantic proximity Read ↗

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620NSemantic proximity Read ↗

Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.Semantic proximity Read ↗

Role of the VPS35 D620N mutation in Parkinson's disease.Semantic proximity Read ↗

Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.Semantic proximity Read ↗

VPS35, the core component of the retromer complex, and Parkinson's diseaseSemantic proximity Read ↗

VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiologySemantic proximity Read ↗

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagySemantic proximity Read ↗

The VPS35 protein and the role of its impairments in mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

VPS35 mutations in Parkinson disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.