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Article

The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress.

The Biochemical journal - 21 Feb 2024

McCarron Katy R, Elcocks Hannah, Mortiboys Heather, Urbé Sylvie, Clague Michael J

Abstract excerpt

The identification of multiple genes linked to Parkinson's disease (PD) invites the question as to how they may co-operate. We have generated isogenic cell lines that inducibly express either wild-type or a mutant form of the retromer component VPS35 (D620N), which has been linked to PD. This has enabled us to test proposed effects of this mutation in a setting where the relative expression reflects the...

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Identifiers

PMID: 38299383
DOI: 10.1042/BCJ20230492
PMCID: PMC10903469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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