Article
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Cell metabolism - 3 Jun 2014
Cerutti Raffaele, Pirinen Eija, Lamperti Costanza, Marchet Silvia, Sauve Anthony A, Li Wei, Leoni Valerio, Schon Eric A, Dantzer Françoise, Auwerx Johan, Viscomi Carlo, Zeviani Massimo
Abstract excerpt
Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects and ameliorate the clinical phenotype in these severely disabling, often fatal, disorders. Pathways related to mitochondrial biogenesis are targets of Sirtuin1,...
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