Article
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
7 Apr 2014
Abstract excerpt
Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD(+)/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease,...
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