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Article

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

7 Apr 2014

Abstract excerpt

Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD(+)/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease,...

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PMID: 24711540
DOI: 10.1002/emmm.201403943

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