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Sirt1 and the Mitochondria

1 Feb 2016

Abstract excerpt

Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1α (PGC-1α) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to...

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PMID: 26831453
DOI: 10.14348/molcells.2016.2318

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