It takes two to tango: NAD+ and sirtuins in aging/longevity control

Abstract excerpt

Abstract The coupling of nicotinamide adenine dinucleotide (NAD + ) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD + and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in diverse organisms. Although the field of sirtuin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Adipose Tissue and Metabolism
• Share to Sirtuins and Resveratrol in Medicine