Article
It takes two to tango: NAD+ and sirtuins in aging/longevity control
18 Aug 2016
Abstract excerpt
Abstract The coupling of nicotinamide adenine dinucleotide (NAD + ) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD + and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in diverse organisms. Although the field of sirtuin...
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