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Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological Therapies

28 Mar 2019

Abstract excerpt

Mitochondrial fatty acid oxidation (FAO) and respiratory chain (RC) defects form a large group of inherited monogenic disorders sharing many common clinical and pathophysiological features, including disruption of mitochondrial bioenergetics, but also, for example, oxidative stress and accumulation of noxious metabolites. Interestingly, several transcription factors or co-activators exert transcriptional control...

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PMID: 30925787
DOI: 10.3390/cells8040289

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