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Article

Pharmacological NAD-Boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-Mutant Fibroblasts.

Molecular pharmacology - 1 Jun 2015

Felici Roberta, Lapucci Andrea, Cavone Leonardo, Pratesi Sara, Berlinguer-Palmini Rolando, Chiarugi Alberto

Abstract excerpt

Mitochondrial disorders are devastating genetic diseases for which efficacious therapies are still an unmet need. Recent studies report that increased availability of intracellular NAD obtained by inhibition of the NAD-consuming enzyme poly(ADP-ribose) polymerase (PARP)-1 or supplementation with the NAD-precursor nicotinamide riboside (NR) ameliorates energetic derangement and symptoms in mouse models of...

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Source

Identifiers

PMID: 25788480
DOI: 10.1124/mol.114.097204

Genes

NDUFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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