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Article

Impact of PICALM and CLU on hippocampal degeneration.

Human brain mapping - 1 Jul 2016

Yang Xianfeng, Li Jin, Liu Bing, Li Yonghui, Jiang Tianzi

Abstract excerpt

PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence suggesting their interaction on amyloid-beta deposition, hence finding functional dependency between their risk genotypes may lead to better understanding of their roles in LOAD development and greater clinical utility. In this study, we mainly investigated interaction effects of risk loci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27017968
DOI: 10.1002/hbm.23183
PMCID: PMC6867347

Genes

CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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