Article
The utility of BRAFV600E mutation-specific antibody for colon cancers with microsatellite instability.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000
Nolan Stephanie, Arnason Thomas, Drucker Arik, Huang Weei-Yuarn
Abstract excerpt
This study's objective was to assess the performance of immunohistochemical staining with the BRAF mutation-specific antibody (clone VE1) in tissue from colon cancers, including those with a high degree of microsatellite instability (MSI-H). VE1 was applied to tissue microarrays of 152 colon cancers with known MSI status. Results of immunohistochemical analyses were scored as negative, positive, or equivocal. The...
Topics
- Algorithms
- Carcinoma
- Colonic Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Epitopes
- False Negative Reactions
- Feasibility Studies
- Humans
- Immunohistochemistry
- Microsatellite Instability