Article
Assessment of BRAF V600E Status in Colorectal Carcinoma: Tissue-Specific Discordances between Immunohistochemistry and Sequencing.
Molecular cancer therapeutics - 1 Dec 2015
Estrella Jeannelyn S, Tetzlaff Michael T, Bassett Roland L, Patel Keyur P, Williams Michelle D, Curry Jonathan L, Rashid Asif, Hamilton Stanley R, Broaddus Russell R
Abstract excerpt
Although sequencing provides the gold standard for identifying colorectal carcinoma with BRAF V600E mutation, immunohistochemistry (IHC) with the recently developed mouse monoclonal antibody VE1 for BRAF V600E protein has shown promise as a more widely available and rapid method. However, we identified anecdotal discordance between VE1 IHC and sequencing results and therefore analyzed VE1 staining by two...
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