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Article

Mutation‐specific antibody detects mutant BRAF<sup>V600E</sup> protein expression in human colon carcinomas

8 May 2013

Abstract excerpt

BACKGROUND: A point mutation (V600E) in the BRAF oncogene is a prognostic biomarker and may predict for nonresponse to anti-EGFR antibody therapy in patients with colorectal carcinoma. BRAFV600E mutations are frequently detected in tumors with microsatellite instability and indicate a sporadic origin. We used a mutation-specific antibody to examine mutant BRAFV600E protein expression and its concordance with...

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PMID: 23657789
DOI: 10.1002/cncr.28133

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