Article
Immunohistochemistry with Anti-BRAF V600E (VE1) Mouse Monoclonal Antibody is a Sensitive Method for Detection of the BRAF V600E Mutation in Colon Cancer: Evaluation of 120 Cases with and without KRAS Mutation and Literature Review.
Pathology oncology research : POR - 1 Jan 2019
Dvorak Katerina, Higgins Amanda, Palting John, Cohen Michael, Brunhoeber Patrick
Abstract excerpt
The major aim of this study was to evaluate the performance of anti-BRAF V600E (VE1) antibody in colorectal tumors with and without KRAS mutation. KRAS and BRAF are two major oncogenic drivers of colorectal cancer (CRC) that have been frequently described as mutually exclusive, thus the BRAF V600...
Topics
- Animals
- Antibodies, Monoclonal
- Biomarkers, Tumor
- Colorectal Neoplasms
- Humans
- Immunohistochemistry
- Mice
- Mutation
- Prognosis
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)