Article
Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia.
Neuro-degenerative diseases - 1 Jan 2017
Wilke Carlo, Gillardon Frank, Deuschle Christian, Hobert Markus A, Jansen Iris E, Metzger Florian G, Heutink Peter, Gasser Thomas, Maetzler Walter, Blauwendraat Cornelis, Synofzik Matthis
Abstract excerpt
BACKGROUND AND OBJECTIVE: Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin gene (GRN). However, alterations of central nervous progranulin expression also occur in neurodegenerative disorders unrelated to GRN mutations, such as Alzheimer's disease. We hypothesised that central nervous progranulin levels are also reduced in...
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