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Article

FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD.

Neurobiology of disease - 15 Jun 2023

Life Benjamin, Petkau Terri L, Cruz Giuliano N F, Navarro-Delgado Erick I, Shen Ning, Korthauer Keegan, Leavitt Blair R

Abstract excerpt

Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene progranulin (GRN). Mouse models of progranulin deficiency have provided insight into progranulin neurobiology, but the description of phenotypes with preclinical relevance has been limited in the currently available heterozygous...

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PMID: 37105261
DOI: 10.1016/j.nbd.2023.106138

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