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Article

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants.

Nature genetics - 1 Sept 1999

Chen C, Kolodner R D

Abstract excerpt

Cancer progression is often associated with the accumulation of gross chromosomal rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions or inversions. In many instances, GCRs inactivate tumour-suppressor genes or generate novel fusion proteins that initiate carcinogenesis. The mechanism underlying GCR formation appears to involve interactions between DNA sequences of...

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Source

Identifiers

PMID: 10471504
DOI: 10.1038/12687

Genes

MRE11
RAD50
LIG4
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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