MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population.

doi:10.1016/j.canep.2010.04.008

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Article

MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population.

Cancer epidemiology - 1 Aug 2010

Akkiz Hikmet, Sümbül Ahmet Taner, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin

Abstract excerpt

BACKGROUND: The mouse double minute 2 (MDM2) gene represents one of the central nodes in the p53 pathway. A naturally occurring T/G single nucleotide polymorphism (SNP) in the intronic promoter of MDM2, SNP309 (rs2279744), was shown to influence MDM2 expression and p53 activity. SNP in the promoter region of MDM2 gene has recently been shown to be associated with accelerated tumor formation in both hereditary and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Neoplasms

Share to Polymorphism, Restriction Fragment Length

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Share to Proto-Oncogene Proteins c-mdm2

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Identifiers

PMID: 20447891
DOI: 10.1016/j.canep.2010.04.008

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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