Article
Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
Nature genetics - 1 Jan 2000
Wu G, Markowitz G S, Li L, D'Agati V D, Factor S M, Geng L, Tibara S, Tuchman J, Cai Y, Park J H, van Adelsberg J, Hou H, Kucherlapati R, Edelmann W, Somlo S
Abstract excerpt
PKD2, mutations in which cause autosomal dominant polycystic kidney disease (ADPKD), encodes an integral membrane glycoprotein with similarity to calcium channel subunits. We induced two mutations in the mouse homologue Pkd2 (ref.4): an unstable allele (WS25; hereafter denoted Pkd2WS25) that can undergo homologous-recombination-based somatic rearrangement to form a null allele; and a true null mutation (WS183;...
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