Article
Role of Plk2 (Snk) in mouse development and cell proliferation.
Molecular and cellular biology - 1 Oct 2003
Ma Sheng, Charron Jean, Erikson Raymond L
Abstract excerpt
Plk2 (Snk) is a polo-like kinase expressed at G(1) in cultured cells and mainly in the hippocampal neurons in the brains of adult rodents, but its function is poorly understood. We have generated mice deficient in Plk2 by gene targeting. Although Plk2 is not required for postnatal growth, Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. The labyrinthine zone of the placenta is...
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