Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.

Cell - 19 Apr 2002

Bhunia Anil Kumar, Piontek Klaus, Boletta Alessandra, Liu Lijuan, Qian Feng, Xu Pei Ning, Germino F Joseph, Germino Gregory G

Abstract excerpt

Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other organs and results from mutations of PKD1 or PKD2. Previous studies suggest that their gene products have an important role in growth regulation. We now show that expression of polycystin-1 activates the JAK-STAT pathway, thereby upregulating p21(waf1) and inducing cell cycle arrest in G0/G1. This process...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G1 Phase

Share to Polycystic Kidney, Autosomal Dominant

Share to Resting Phase, Cell Cycle

Share to STAT1 Transcription Factor

Share to STAT3 Transcription Factor

Share to TRPP Cation Channels

Source

Identifiers

PMID: 12007403
DOI: 10.1016/s0092-8674(02)00716-x

Genes

PKD1
PKD2
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.PMID 12007403Read ↗

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.Semantic proximity Read ↗

Molecular genetics of polycystic kidney disease.Semantic proximity Read ↗

Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Semantic proximity Read ↗

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2.Semantic proximity Read ↗

Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial CellsSemantic proximity Read ↗

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.Semantic proximity Read ↗

Molecular basis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.Semantic proximity Read ↗

The genetics and physiology of polycystic kidney disease.Semantic proximity Read ↗

Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.Semantic proximity Read ↗

Renal expression of JAK2 is high in polycystic kidney disease and its inhibition reduces cystogenesisSemantic proximity Read ↗

Phosphorylation, protein kinases and ADPKD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.