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Article

Polo-like kinase 1 is essential for early embryonic development and tumor suppression.

Molecular and cellular biology - 1 Nov 2008

Lu Lin-Yu, Wood Jamie L, Minter-Dykhouse Katherine, Ye Lin, Saunders Thomas L, Yu Xiaochun, Chen Junjie

Abstract excerpt

Polo-like kinases (Plks) are serine/threonine kinases that are highly conserved in organisms from yeasts to humans. Previous reports have shown that Plk1 is critical for all stages of mitosis and may play a role in DNA replication during S phase. While much work has focused on Plk1, little is known about the physiological function of Plk1 in vivo. To address this question, we generated Plk1 knockout mice. Plk1...

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Identifiers

PMID: 18794363
DOI: 10.1128/MCB.00392-08
PMCID: PMC2573299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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