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Article

Dosage compensation of an aneuploid genome in mouse spermatogenic cells.

Biology of reproduction - 1 Jun 2014

Jansa Petr, Homolka David, Blatny Radek, Mistrik Martin, Bartek Jiri, Forejt Jiri

Abstract excerpt

Autosomal trisomies and monosomies bring serious threats to embryonic development through transcriptional disarray caused primarily by the dosage effect of the aneuploid part of the genome. The present study compared the effect of a mouse-viable 30-Mb segmental trisomy on the genome-wide transcriptional profile of somatic (liver) cells and male germ cells. Although the 1.6-fold change in expression of triplicated...

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Source

Identifiers

PMID: 24790161
DOI: 10.1095/biolreprod.114.118497

Genes

HORMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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