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Article

Dosage compensation of the sex chromosomes.

Annual review of genetics - 1 Jan 2012

Disteche Christine M

Abstract excerpt

Differentiated sex chromosomes evolved because of suppressed recombination once sex became genetically controlled. In XX/XY and ZZ/ZW systems, the heterogametic sex became partially aneuploid after degeneration of the Y or W. Often, aneuploidy causes abnormal levels of gene expression throughout the entire genome. Dosage compensation mechanisms evolved to restore balanced expression of the genome. These...

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Identifiers

PMID: 22974302
DOI: 10.1146/annurev-genet-110711-155454
PMCID: PMC3767307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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