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Aneuploidy and Gene Expression: Is there Dosage Compensation?

22 Nov 2019

Abstract excerpt

Aneuploidy (i.e., abnormal chromosome number) is the leading cause of miscarriage and congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer. The deleterious phenotypes associated with aneuploidy are likely a result of the imbalance in the levels of gene products derived from the additional chromosome(s). Here, we summarize the current knowledge on how the presence of extra chromosomes impacts...

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PMID: 31755744
DOI: 10.2217/epi-2019-0135

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