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Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help

1 May 2014

Abstract excerpt

X linked lymphoproliferative disease (XLP) is an inherited immunodeficiency resulting from mutations in the gene encoding the slam associated protein (SAP). One of the defining characteristics of XLP is extreme susceptibility to infection with Epstein-Barr virus (EBV), a gammaherpesvirus belonging to the genus Lymphocryptovirus, often resulting in fatal infectious mononucleosis (FIM). However, infection of SAP...

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PMID: 24789087
DOI: 10.1371/journal.ppat.1004106

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