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Article

SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2007

McCausland Megan M, Yusuf Isharat, Tran Hung, Ono Nobuyuki, Yanagi Yusuke, Crotty Shane

Abstract excerpt

Mutations in SH2D1A resulting in lack of SLAM-associated protein (SAP) expression cause the human genetic immunodeficiency X-linked lymphoproliferative disease. A severe block in germinal center development and lack of long-term humoral immunity is one of the most prominent phenotypes of SAP(-) mice. We show, in this study, that the germinal center block is due to an essential requirement for SAP expression in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17202343
DOI: 10.4049/jimmunol.178.2.817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.PMID 17202343Read ↗

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