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Article

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

PLoS biology - 1 Nov 2011

Palendira Umaimainthan, Low Carol, Chan Anna, Hislop Andrew D, Ho Edwin, Phan Tri Giang, Deenick Elissa, Cook Matthew C, Riminton D Sean, Choo Sharon, Loh Richard, Alvaro Frank, Booth Claire, Gaspar H Bobby, Moretta Alessandro, Khanna Rajiv, Rickinson Alan B, Tangye Stuart G

Abstract excerpt

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP. SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors. A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotr...

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Share to Epstein-Barr Virus Infections
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza, Human

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Share to Signaling Lymphocytic Activation Molecule Associated Protein

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Source

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Identifiers

PMID: 22069374
DOI: 10.1371/journal.pbio.1001187
PMCID: PMC3206011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22069374-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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