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Article

Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2007

Kim In-Jeong, Burkum Claire E, Cookenham Tres, Schwartzberg Pamela L, Woodland David L, Blackman Marcia A

Abstract excerpt

Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP)) interactions with SLAM family proteins play important roles in immune function. SAP-deficient mice have defective B cell function, including impairment of germinal center formation, production of class-switched Ig, and development of memory B cells. B cells are the major reservoir of latency for both EBV and the homologous murine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17237419
DOI: 10.4049/jimmunol.178.3.1692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs.PMID 17237419Read ↗

SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.Semantic proximity Read ↗

Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular HelpSemantic proximity Read ↗

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.Semantic proximity Read ↗

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of MoleculesSemantic proximity Read ↗

Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient MiceSemantic proximity Read ↗

SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semantic proximity Read ↗

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.Semantic proximity Read ↗

The M4 gene of gammaHV68 encodes a secreted glycoprotein and is required for the efficient establishment of splenic latency.Semantic proximity Read ↗

SLAM family receptors and SAP adaptors in immunity.Semantic proximity Read ↗

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.Semantic proximity Read ↗

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