Article
Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells.
Immunology - 1 Jun 2013
Gauld Stephen B, De Santis Jessica L, Kulinski Joseph M, McGraw Jennifer A, Leonardo Steven M, Ruder Elizabeth A, Maier Weston, Tarakanova Vera L
Abstract excerpt
Viruses such as Epstein-Barr virus (EBV) have been linked to mechanisms that support autoantibody production in diseases such as systemic lupus erythematosus. However, the mechanisms by which viruses contribute to autoantibody production remain poorly defined. This stems in part, from the high level of seropositivity for EBV (> 95%) and the exquisite species specificity of EBV. In this study we overcame these...
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