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Article

Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala.

Translational psychiatry - 11 Feb 2014

Sotnikov S V, Markt P O, Malik V, Chekmareva N Y, Naik R R, Sah A, Singewald N, Holsboer F, Czibere L, Landgraf R

Abstract excerpt

The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition, gene x environment and epigenetic interactions. Accordingly, inborn anxiety is considered a polygenic, multifactorial trait, likely to be shaped by environmentally driven plasticity at the genomic level. We here took advantage of the extreme genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24518397
DOI: 10.1038/tp.2013.127
PMCID: PMC3944631

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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